Assay Detail
Binding
CHEMBL3256389
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Antagonist activity at angiotensin 2 receptor in Sprague-Dawley rat uterus assessed as reduction of angiotensin 2-induced response pretreated for 2 mins followed by angiotensin 2 challenge for every 12 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.80 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 8.60 |
| CHEMBL3249921 | — | — | 1 | 8.40 |
| CHEMBL3249554 | — | — | 1 | 8.10 |
| CHEMBL3249556 | — | — | 1 | 7.70 |
| CHEMBL3244481 | — | — | 1 | 7.40 |
| CHEMBL3249557 | — | — | 1 | 7.40 |
| CHEMBL3249555 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL3249921 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL3249554 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL3249556 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL3244481 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL3249557 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL3249555 | — | Kd | = | 100.0 | nM | 7.00 |