Assay Detail
Binding
CHEMBL3258305
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Competitive antagonist at angiotensin 2 receptor in rabbit aorta assessed as rightward shift in angiotensin-2 dose response curve for myotropic activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists by incorporating alpha-methylalanine or O-methylthreonine residues in angiotension II analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.78 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370903 | — | — | 1 | 9.50 |
| CHEMBL3248820 | — | — | 1 | 9.50 |
| CHEMBL404594 | — | — | 1 | 9.17 |
| CHEMBL2371400 | — | — | 1 | 8.79 |
| CHEMBL2371388 | — | — | 1 | 8.78 |
| CHEMBL3248823 | — | — | 1 | 8.76 |
| CHEMBL3248821 | — | — | 1 | 8.70 |
| CHEMBL312754 | — | — | 1 | 8.61 |
| CHEMBL3248822 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370903 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL3248820 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL404594 | — | Kd | = | 0.6761 | nM | 9.17 |
| CHEMBL2371400 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL2371388 | — | Kd | = | 1.66 | nM | 8.78 |
| CHEMBL3248823 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL3248821 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL312754 | — | Kd | = | 2.455 | nM | 8.61 |
| CHEMBL3248822 | — | Kd | = | 60.26 | nM | 7.22 |