Assay Detail
Binding
CHEMBL3259187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive reversible inhibition of bovine trypsin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 30 mins by Michaelis-Menten plot analysis
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 62 | 5.13 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99951 | — | — | 1 | 7.77 |
| CHEMBL101672 | — | — | 1 | 5.84 |
| CHEMBL168077 | — | — | 1 | 5.67 |
| CHEMBL279962 | — | — | 1 | 5.65 |
| CHEMBL167983 | — | — | 1 | 5.60 |
| CHEMBL167255 | — | — | 1 | 5.59 |
| CHEMBL3251534 | — | — | 1 | 5.56 |
| CHEMBL102148 | — | — | 1 | 5.53 |
| CHEMBL3251529 | — | — | 1 | 5.49 |
| CHEMBL165312 | — | — | 1 | 5.49 |
| CHEMBL167845 | — | — | 1 | 5.48 |
| CHEMBL167801 | — | — | 1 | 5.47 |
| CHEMBL289577 | — | — | 1 | 5.42 |
| CHEMBL352923 | — | — | 1 | 5.41 |
| CHEMBL103649 | — | — | 1 | 5.40 |
| CHEMBL3251186 | — | — | 1 | 5.38 |
| CHEMBL3251191 | — | — | 1 | 5.38 |
| CHEMBL352553 | — | — | 1 | 5.38 |
| CHEMBL356487 | — | — | 1 | 5.33 |
| CHEMBL3251527 | — | — | 1 | 5.33 |
| CHEMBL167762 | — | — | 1 | 5.33 |
| CHEMBL52393 | — | — | 1 | 5.31 |
| CHEMBL48217 | DAPI | — | 1 | 5.28 |
| CHEMBL164947 | — | — | 1 | 5.24 |
| CHEMBL297809 | — | — | 1 | 5.23 |
| CHEMBL101261 | — | — | 1 | 5.22 |
| CHEMBL167761 | — | — | 1 | 5.21 |
| CHEMBL3251528 | — | — | 1 | 5.19 |
| CHEMBL3251192 | — | — | 1 | 5.18 |
| CHEMBL166236 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99951 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL101672 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL168077 | — | Ki | = | 2130.0 | nM | 5.67 |
| CHEMBL279962 | — | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL167983 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL167255 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL3251534 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL102148 | — | Ki | = | 2960.0 | nM | 5.53 |
| CHEMBL3251529 | — | Ki | = | 3230.0 | nM | 5.49 |
| CHEMBL165312 | — | Ki | = | 3250.0 | nM | 5.49 |
| CHEMBL167845 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL167801 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL289577 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL352923 | — | Ki | = | 3940.0 | nM | 5.41 |
| CHEMBL103649 | — | Ki | = | 4010.0 | nM | 5.40 |
| CHEMBL3251186 | — | Ki | = | 4160.0 | nM | 5.38 |
| CHEMBL352553 | — | Ki | = | 4170.0 | nM | 5.38 |
| CHEMBL3251191 | — | Ki | = | 4190.0 | nM | 5.38 |
| CHEMBL356487 | — | Ki | = | 4680.0 | nM | 5.33 |
| CHEMBL3251527 | — | Ki | = | 4670.0 | nM | 5.33 |
| CHEMBL167762 | — | Ki | = | 4730.0 | nM | 5.33 |
| CHEMBL52393 | — | Ki | = | 4930.0 | nM | 5.31 |
| CHEMBL48217 | DAPI | Ki | = | 5310.0 | nM | 5.28 |
| CHEMBL164947 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL297809 | — | Ki | = | 5880.0 | nM | 5.23 |
| CHEMBL101261 | — | Ki | = | 5980.0 | nM | 5.22 |
| CHEMBL167761 | — | Ki | = | 6170.0 | nM | 5.21 |
| CHEMBL3251528 | — | Ki | = | 6520.0 | nM | 5.19 |
| CHEMBL3251192 | — | Ki | = | 6570.0 | nM | 5.18 |
| CHEMBL166236 | — | Ki | = | 6670.0 | nM | 5.18 |
| CHEMBL3251535 | — | Ki | = | 7110.0 | nM | 5.15 |
| CHEMBL354342 | — | Ki | = | 7270.0 | nM | 5.14 |
| CHEMBL500330 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL3244501 | — | Ki | = | 9320.0 | nM | 5.03 |
| CHEMBL297403 | — | Ki | = | 9460.0 | nM | 5.02 |
| CHEMBL1233459 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL3251538 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL388768 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL3251190 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL3251187 | — | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL1688696 | — | Ki | = | 14600.0 | nM | 4.84 |
| CHEMBL164489 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL3251537 | — | Ki | = | 16200.0 | nM | 4.79 |
| CHEMBL417907 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL563834 | — | Ki | = | 17100.0 | nM | 4.77 |
| CHEMBL3251536 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3251185 | — | Ki | = | 19400.0 | nM | 4.71 |
| CHEMBL3251189 | — | Ki | = | 24400.0 | nM | 4.61 |
| CHEMBL3251188 | — | Ki | = | 27200.0 | nM | 4.57 |
| CHEMBL145656 | — | Ki | = | 27800.0 | nM | 4.56 |