Assay Detail
Binding
CHEMBL3265733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Discoidin domain-containing receptor 2 (CHEMBL5122) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of type II and III DDR2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 32 | 6.85 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568875 | — | — | 1 | 7.82 |
| CHEMBL498947 | — | — | 1 | 7.82 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.75 |
| CHEMBL344800 | — | — | 1 | 7.70 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.68 |
| CHEMBL3261118 | — | — | 1 | 7.52 |
| CHEMBL1738943 | — | — | 1 | 7.20 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 7.12 |
| CHEMBL2403816 | — | — | 1 | 7.03 |
| CHEMBL522387 | — | — | 1 | 6.75 |
| CHEMBL420047 | — | — | 1 | 6.60 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.50 |
| CHEMBL1738945 | — | — | 1 | 6.42 |
| CHEMBL1940504 | — | — | 1 | 6.42 |
| CHEMBL1940500 | — | — | 1 | 6.39 |
| CHEMBL583263 | — | — | 1 | 6.38 |
| CHEMBL253969 | OSI-632 | 2.0 | 1 | 6.38 |
| CHEMBL3261116 | — | — | 1 | 6.37 |
| CHEMBL578172 | — | — | 1 | 6.37 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 6.24 |
| CHEMBL1738946 | — | — | 1 | 6.15 |
| CHEMBL3261119 | — | — | 1 | 6.04 |
| CHEMBL3261120 | — | — | 1 | - |
| CHEMBL87580 | — | — | 1 | - |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | - |
| CHEMBL3261121 | — | — | 1 | - |
| CHEMBL476011 | — | — | 1 | - |
| CHEMBL1738942 | — | — | 1 | - |
| CHEMBL2403875 | — | — | 1 | - |
| CHEMBL3261117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568875 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL498947 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL5416410 | DASATINIB | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL344800 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL3261118 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL1738943 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL255863 | NILOTINIB | Kd | = | 75.0 | nM | 7.12 |
| CHEMBL2403816 | — | Kd | = | 93.0 | nM | 7.03 |
| CHEMBL522387 | — | Kd | = | 178.0 | nM | 6.75 |
| CHEMBL420047 | — | Kd | = | 252.0 | nM | 6.60 |
| CHEMBL1336 | SORAFENIB | Kd | = | 313.0 | nM | 6.50 |
| CHEMBL1738945 | — | Kd | = | 382.0 | nM | 6.42 |
| CHEMBL1940504 | — | Kd | = | 385.0 | nM | 6.42 |
| CHEMBL1940500 | — | Kd | = | 406.0 | nM | 6.39 |
| CHEMBL253969 | OSI-632 | Kd | = | 422.0 | nM | 6.38 |
| CHEMBL583263 | — | Kd | = | 412.0 | nM | 6.38 |
| CHEMBL3261116 | — | Kd | = | 424.0 | nM | 6.37 |
| CHEMBL578172 | — | Kd | = | 428.0 | nM | 6.37 |
| CHEMBL477772 | PAZOPANIB | Kd | = | 581.0 | nM | 6.24 |
| CHEMBL1738946 | — | Kd | = | 702.0 | nM | 6.15 |
| CHEMBL3261119 | — | Kd | = | 915.0 | nM | 6.04 |
| CHEMBL3261120 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL87580 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL572878 | TOZASERTIB | Kd | > | 2500.0 | nM | - |
| CHEMBL3261121 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL476011 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL1738942 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2403875 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL3261117 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL1940505 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL1940503 | — | Kd | > | 1000.0 | nM | - |