Assay Detail
Binding
CHEMBL3266323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from Wistar Hannover rat liver sigma 2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.65 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259961 | — | — | 1 | 8.18 |
| CHEMBL3259962 | — | — | 1 | 8.16 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.61 |
| CHEMBL3259960 | — | — | 1 | 7.51 |
| CHEMBL3259963 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259961 | — | Ki | = | 6.57 | nM | 8.18 |
| CHEMBL3259962 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL3259960 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL3259963 | — | Ki | = | 161.0 | nM | 6.79 |