Assay Detail
Functional
CHEMBL3266495
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Antimalarial activity against atovaquone-resistant clinical isolate Plasmodium falciparum TM90-C2B infected in human red blood cells assessed as suppression of parasitemia after 72 hrs by SYBR Green I-based fluorescence method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 8.59 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261733 | — | — | 1 | 10.30 |
| CHEMBL3259839 | — | — | 1 | 9.70 |
| CHEMBL3261736 | — | — | 1 | 9.52 |
| CHEMBL3261738 | — | — | 1 | 9.40 |
| CHEMBL3261731 | — | — | 1 | 9.30 |
| CHEMBL1258013 | — | — | 1 | 9.10 |
| CHEMBL3261734 | — | — | 1 | 8.92 |
| CHEMBL2431810 | — | — | 1 | 8.85 |
| CHEMBL3261740 | — | — | 1 | 8.82 |
| CHEMBL3261730 | — | — | 1 | 8.77 |
| CHEMBL3261728 | — | — | 1 | 8.64 |
| CHEMBL3261727 | — | — | 1 | 8.64 |
| CHEMBL3261953 | — | — | 1 | 8.39 |
| CHEMBL3261741 | — | — | 1 | 8.37 |
| CHEMBL3261737 | — | — | 1 | 8.24 |
| CHEMBL3261726 | — | — | 1 | 8.14 |
| CHEMBL2030049 | — | — | 1 | 8.12 |
| CHEMBL3261729 | — | — | 1 | 8.07 |
| CHEMBL527822 | — | — | 1 | 7.96 |
| CHEMBL3261952 | — | — | 1 | 7.96 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 5.11 |
| CHEMBL3261735 | — | — | 1 | - |
| CHEMBL3261739 | — | — | 1 | - |
| CHEMBL3261732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261733 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3259839 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3261736 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3261738 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3261731 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1258013 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3261734 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2431810 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3261740 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3261730 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3261728 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3261727 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3261953 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3261741 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3261737 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3261726 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2030049 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3261729 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL527822 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3261952 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1450 | ATOVAQUONE | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3261735 | — | EC50 | - | — | - | |
| CHEMBL3261739 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL3261732 | — | EC50 | < | 0.03 | nM | - |