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Assay Detail

CHEMBL3266497

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.
J Med Chem (2014) 57 : 3818 -3834
PubMed 24720377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.06 6.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1450 ATOVAQUONE 4.0 1 6.39
CHEMBL2030049 1 5.72
CHEMBL527822 1 -
CHEMBL1258013 1 -
CHEMBL3261726 1 -
CHEMBL3261727 1 -
CHEMBL3261728 1 -
CHEMBL2431810 1 -
CHEMBL3261729 1 -
CHEMBL3261730 1 -
CHEMBL3261731 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1450 ATOVAQUONE IC50 = 410.0 nM 6.39
CHEMBL2030049 IC50 = 1900.0 nM 5.72
CHEMBL527822 IC50 > 10000.0 nM -
CHEMBL1258013 IC50 > 10000.0 nM -
CHEMBL3261726 IC50 - -
CHEMBL3261727 IC50 > 10000.0 nM -
CHEMBL3261728 IC50 > 10000.0 nM -
CHEMBL2431810 IC50 > 10000.0 nM -
CHEMBL3261729 IC50 - -
CHEMBL3261730 IC50 > 10000.0 nM -
CHEMBL3261731 IC50 > 10000.0 nM -