Assay Detail

CHEMBL3266503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of cytochrome bc1 complex isolated from trophozoite stage Plasmodium falciparum

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Plasmodium falciparum
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.
J Med Chem (2014) 57 : 3818 -3834
PubMed 24720377 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.38	8.70
EC50	1	9.25	9.25

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2431810	—	—	1	9.25
CHEMBL1450	ATOVAQUONE	4.0	1	8.70
CHEMBL2030049	—	—	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2431810	—	EC50	=	0.56	nM	9.25
CHEMBL1450	ATOVAQUONE	IC50	=	2.0	nM	8.70
CHEMBL2030049	—	IC50	=	8.9	nM	8.05