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Assay Detail

CHEMBL3266505

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum TM93-C1088 assessed as suppression of parasitemia after 72 hrs by SYBR Green I-based fluorescence method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.
J Med Chem (2014) 57 : 3818 -3834
PubMed 24720377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 9.00 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2431810 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2431810 EC50 = 1.0 nM 9.00