Assay Detail
Binding
CHEMBL3266567
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Binding affinity to HIV1 integrase by displacement assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.88 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259901 | — | — | 1 | 7.40 |
| CHEMBL3259897 | — | — | 1 | 7.32 |
| CHEMBL3259898 | — | — | 1 | 7.31 |
| CHEMBL3259896 | — | — | 1 | 7.21 |
| CHEMBL3259899 | — | — | 1 | 7.17 |
| CHEMBL3259900 | — | — | 1 | 6.85 |
| CHEMBL3259895 | — | — | 1 | 6.82 |
| CHEMBL3259894 | — | — | 1 | 6.55 |
| CHEMBL3259893 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259901 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL3259897 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL3259898 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL3259896 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL3259899 | — | Kd | = | 68.0 | nM | 7.17 |
| CHEMBL3259900 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL3259895 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL3259894 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL3259893 | — | Kd | = | 4700.0 | nM | 5.33 |