Assay Detail
Binding
CHEMBL3266696
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Inhibition of recombinant human cathepsin C using H-Gly-Arg-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.28 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261927 | — | — | 1 | 9.10 |
| CHEMBL3261926 | — | — | 1 | 9.00 |
| CHEMBL212521 | — | — | 1 | 8.70 |
| CHEMBL3261925 | — | — | 1 | 8.70 |
| CHEMBL3261924 | — | — | 1 | 8.60 |
| CHEMBL3261920 | — | — | 1 | 8.40 |
| CHEMBL3261923 | — | — | 1 | 8.40 |
| CHEMBL3261922 | — | — | 1 | 8.30 |
| CHEMBL3261928 | — | — | 1 | 8.30 |
| CHEMBL3261921 | — | — | 1 | 7.60 |
| CHEMBL3261919 | — | — | 1 | 7.40 |
| CHEMBL3261918 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261927 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL3261926 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212521 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3261925 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3261924 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3261920 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3261923 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3261922 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3261928 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3261921 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3261919 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3261918 | — | IC50 | = | 125.89 | nM | 6.90 |