Assay Detail
Binding
CHEMBL3266700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by electrophysiology assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.26 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261919 | — | — | 1 | 5.85 |
| CHEMBL3261920 | — | — | 1 | 5.57 |
| CHEMBL3261924 | — | — | 1 | 5.05 |
| CHEMBL3261926 | — | — | 1 | 4.58 |
| CHEMBL3261921 | — | — | 1 | - |
| CHEMBL3261922 | — | — | 1 | - |
| CHEMBL3261923 | — | — | 1 | - |
| CHEMBL3261925 | — | — | 1 | - |
| CHEMBL3261927 | — | — | 1 | - |
| CHEMBL3261928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261919 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3261920 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3261924 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3261926 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3261921 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3261922 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3261923 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3261925 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3261927 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3261928 | — | IC50 | > | 33000.0 | nM | - |