Assay Detail
Binding
CHEMBL3266758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified bovine eNOS assessed as inhibition of nitric oxide-mediated oxidation of hemoglobin-A by hemoglobin capture assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.77 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262019 | — | — | 1 | 5.44 |
| CHEMBL3262022 | — | — | 1 | 5.32 |
| CHEMBL3262018 | — | — | 1 | 4.84 |
| CHEMBL3262024 | — | — | 1 | 4.80 |
| CHEMBL3262025 | — | — | 1 | 4.71 |
| CHEMBL3262026 | — | — | 1 | 4.16 |
| CHEMBL3262017 | — | — | 1 | 4.15 |
| CHEMBL3262020 | — | — | 1 | - |
| CHEMBL3262021 | — | — | 1 | - |
| CHEMBL3262023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262019 | — | Ki | = | 3610.0 | nM | 5.44 |
| CHEMBL3262022 | — | Ki | = | 4770.0 | nM | 5.32 |
| CHEMBL3262018 | — | Ki | = | 14390.0 | nM | 4.84 |
| CHEMBL3262024 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3262025 | — | Ki | = | 19417.0 | nM | 4.71 |
| CHEMBL3262026 | — | Ki | = | 68520.0 | nM | 4.16 |
| CHEMBL3262017 | — | Ki | = | 70900.0 | nM | 4.15 |
| CHEMBL3262020 | — | Ki | = | 328000.0 | nM | - |
| CHEMBL3262021 | — | Ki | = | 1049000.0 | nM | - |
| CHEMBL3262023 | — | Ki | = | 133174.0 | nM | - |