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Assay Detail

CHEMBL3266785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
Huang G, Kling B, Darras FH, Heilmann J, Decker M.
Eur J Med Chem (2014) 81 : 15 -21
PubMed 24819955 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.82 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94 PHYSOSTIGMINE 3.0 1 8.11
CHEMBL3262479 1 5.52
CHEMBL3262481 1 -
CHEMBL3262482 1 -
CHEMBL3262483 1 -
CHEMBL3262484 1 -
CHEMBL3262485 1 -
CHEMBL3262486 1 -
CHEMBL3262487 1 -
CHEMBL3262488 1 -
CHEMBL3262489 1 -
CHEMBL3262490 1 -
CHEMBL3262491 1 -
CHEMBL3262492 1 -
CHEMBL81925 1 -
CHEMBL2171768 1 -
CHEMBL2171793 1 -
CHEMBL3262480 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94 PHYSOSTIGMINE IC50 = 7.7 nM 8.11
CHEMBL3262479 IC50 = 3010.0 nM 5.52
CHEMBL3262481 IC50 > 10000.0 nM -
CHEMBL3262482 IC50 > 10000.0 nM -
CHEMBL3262483 IC50 > 10000.0 nM -
CHEMBL3262484 IC50 > 10000.0 nM -
CHEMBL3262485 IC50 > 10000.0 nM -
CHEMBL3262486 IC50 > 10000.0 nM -
CHEMBL3262487 IC50 > 10000.0 nM -
CHEMBL3262488 IC50 > 10000.0 nM -
CHEMBL3262489 IC50 > 10000.0 nM -
CHEMBL3262490 IC50 > 10000.0 nM -
CHEMBL3262491 IC50 > 10000.0 nM -
CHEMBL3262492 IC50 > 10000.0 nM -
CHEMBL81925 IC50 > 10000.0 nM -
CHEMBL2171768 IC50 > 10000.0 nM -
CHEMBL2171793 IC50 > 100000.0 nM -
CHEMBL3262480 IC50 > 100000.0 nM -