Assay Detail
Binding
CHEMBL3266883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Flu-BID/FAM-BID from His-tagged A1-BFL-1 (1 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.40 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3265297 | — | — | 1 | 5.96 |
| CHEMBL3265294 | — | — | 1 | 5.63 |
| CHEMBL3265295 | — | — | 1 | 5.50 |
| CHEMBL3265299 | — | — | 1 | 5.47 |
| CHEMBL1331211 | — | — | 1 | 5.27 |
| CHEMBL2030270 | — | — | 1 | 5.21 |
| CHEMBL3265296 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3265297 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL3265294 | — | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL3265295 | — | Ki | = | 3180.0 | nM | 5.50 |
| CHEMBL3265299 | — | Ki | = | 3360.0 | nM | 5.47 |
| CHEMBL1331211 | — | Ki | = | 5330.0 | nM | 5.27 |
| CHEMBL2030270 | — | Ki | = | 6140.0 | nM | 5.21 |
| CHEMBL3265296 | — | Ki | = | 17260.0 | nM | 4.76 |