Assay Detail
Functional
CHEMBL3267206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MV4-11 cells assessed as intracellular ATP level after 3 days by CellTiterGlo assay
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 9 | - | - |
| IC50 | 9 | 5.20 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3265297 | — | — | 2 | 5.37 |
| CHEMBL3265299 | — | — | 2 | 5.37 |
| CHEMBL3265295 | — | — | 2 | 5.33 |
| CHEMBL3265294 | — | — | 2 | 5.26 |
| CHEMBL3265309 | — | — | 2 | 5.22 |
| CHEMBL3265313 | — | — | 2 | 5.18 |
| CHEMBL1331211 | — | — | 2 | 4.96 |
| CHEMBL3260032 | — | — | 2 | 4.93 |
| CHEMBL3260036 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3265297 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL3265299 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL3265295 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL3265294 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL3265309 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL3265313 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL1331211 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL3260032 | — | IC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL3265294 | — | Activity | - | — | - | |
| CHEMBL3265295 | — | Activity | - | — | - | |
| CHEMBL3265297 | — | Activity | - | — | - | |
| CHEMBL3265299 | — | Activity | - | — | - | |
| CHEMBL3265309 | — | Activity | - | — | - | |
| CHEMBL3265313 | — | Activity | - | — | - | |
| CHEMBL3260032 | — | Activity | - | — | - | |
| CHEMBL3260036 | — | Activity | - | — | - | |
| CHEMBL1331211 | — | Activity | - | — | - | |
| CHEMBL3260036 | — | IC50 | > | 50000.0 | nM | - |