Assay Detail
Functional
CHEMBL3267242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucose-dependent insulinotropic receptor (CHEMBL5263) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.34 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260533 | — | — | 1 | 7.72 |
| CHEMBL3260540 | — | — | 1 | 7.41 |
| CHEMBL3260536 | — | — | 1 | 7.31 |
| CHEMBL3260518 | — | — | 1 | 7.12 |
| CHEMBL3260506 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260533 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3260540 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3260536 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3260518 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3260506 | — | EC50 | = | 76.0 | nM | 7.12 |