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Assay Detail

CHEMBL3267339

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Functional
Agonist activity at human recombinant adenosine receptor A2b by cAMP assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2b (CHEMBL255)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adenosine A2A receptor as a drug discovery target.
de Lera Ruiz M, Lim YH, Zheng J.
J Med Chem (2014) 57 : 3623 -3650
PubMed 24164628 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.37 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464859 NECA 1 6.48
CHEMBL186113 GW-328267 1.0 1 5.89
CHEMBL3350613 1 5.21
CHEMBL317052 REGADENOSON ANHYDROUS 4.0 1 5.00
CHEMBL1950553 SONEDENOSON 2.0 1 5.00
CHEMBL477 ADENOSINE 4.0 1 4.62
CHEMBL285819 1 -
CHEMBL1256672 1 -
CHEMBL331372 CGS-21680 1 -
CHEMBL1950554 BINODENOSON 3.0 1 -
CHEMBL1950649 APADENOSON 3.0 1 -
CHEMBL3260724 1 -
CHEMBL487497 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464859 NECA EC50 = 330.0 nM 6.48
CHEMBL186113 GW-328267 EC50 = 1300.0 nM 5.89
CHEMBL3350613 EC50 = 6100.0 nM 5.21
CHEMBL317052 REGADENOSON ANHYDROUS EC50 = 10000.0 nM 5.00
CHEMBL1950553 SONEDENOSON EC50 = 10000.0 nM 5.00
CHEMBL477 ADENOSINE EC50 = 24000.0 nM 4.62
CHEMBL285819 EC50 - -
CHEMBL1256672 EC50 - -
CHEMBL331372 CGS-21680 EC50 = 361000.0 nM -
CHEMBL1950554 BINODENOSON EC50 > 100000.0 nM -
CHEMBL1950649 APADENOSON EC50 - -
CHEMBL3260724 EC50 - -
CHEMBL487497 EC50 - -