Assay Detail
Binding
CHEMBL3267591
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Inhibition of full-length ITK (unknown origin) using biotin-EQEDEPEGIYGVLF-NH2 as substrate by plate reader analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.19 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263053 | — | — | 1 | 10.00 |
| CHEMBL3263055 | — | — | 1 | 9.64 |
| CHEMBL3263050 | — | — | 1 | 9.25 |
| CHEMBL3263036 | — | — | 1 | 9.10 |
| CHEMBL3263054 | — | — | 1 | 9.10 |
| CHEMBL3263052 | — | — | 1 | 9.03 |
| CHEMBL3263049 | — | — | 1 | 9.00 |
| CHEMBL3263035 | — | — | 1 | 8.85 |
| CHEMBL3263039 | — | — | 1 | 8.77 |
| CHEMBL3263038 | — | — | 1 | 8.47 |
| CHEMBL3263051 | — | — | 1 | 8.18 |
| CHEMBL3263037 | — | — | 1 | 8.11 |
| CHEMBL3262783 | — | — | 1 | 8.00 |
| CHEMBL3263044 | — | — | 1 | 7.96 |
| CHEMBL3262780 | — | — | 1 | 7.82 |
| CHEMBL3263046 | — | — | 1 | 7.57 |
| CHEMBL3263047 | — | — | 1 | 7.46 |
| CHEMBL3263045 | — | — | 1 | 7.44 |
| CHEMBL3263048 | — | — | 1 | 7.36 |
| CHEMBL3263043 | — | — | 1 | 7.28 |
| CHEMBL3262782 | — | — | 1 | 7.23 |
| CHEMBL3263042 | — | — | 1 | 6.42 |
| CHEMBL3262781 | — | — | 1 | 6.24 |
| CHEMBL3263041 | — | — | 1 | - |
| CHEMBL3263040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263053 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3263055 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL3263050 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL3263036 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3263054 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3263052 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL3263049 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3263035 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3263039 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3263038 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL3263051 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL3263037 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3262783 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3263044 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3262780 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3263046 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3263047 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3263045 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3263048 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL3263043 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3262782 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL3263042 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL3262781 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3263041 | — | Ki | > | 4.0 | nM | - |
| CHEMBL3263040 | — | Ki | > | 4.0 | nM | - |