Assay Detail
Binding
CHEMBL3267592
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Inhibition of ITK in human Jurkat cells assessed as decrease in phosphorylation of PLC-gamma1 by immunodetection assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.53 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263055 | — | — | 1 | 7.36 |
| CHEMBL3263053 | — | — | 1 | 6.76 |
| CHEMBL3263036 | — | — | 1 | 6.64 |
| CHEMBL3262780 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263055 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3263053 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3263036 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL3262780 | — | IC50 | = | 4600.0 | nM | 5.34 |