Assay Detail
Functional
CHEMBL3267607
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Inhibition of P2Y1 receptor in human washed platelets assessed as decrease in 2-methylthio-ADP-induced calcium signal transduction pathway activation by FLIPR assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.90 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263066 | — | — | 1 | 10.10 |
| CHEMBL3263056 | — | — | 1 | 9.92 |
| CHEMBL3263057 | — | — | 1 | 9.72 |
| CHEMBL3263076 | — | — | 1 | 9.70 |
| CHEMBL3263067 | — | — | 1 | 9.68 |
| CHEMBL3263069 | — | — | 1 | 9.49 |
| CHEMBL3263068 | — | — | 1 | 9.47 |
| CHEMBL3263071 | — | — | 1 | 9.20 |
| CHEMBL3263075 | — | — | 1 | 8.82 |
| CHEMBL3263074 | — | — | 1 | 8.80 |
| CHEMBL3263062 | — | — | 1 | 8.64 |
| CHEMBL3263070 | — | — | 1 | 8.57 |
| CHEMBL3263073 | — | — | 1 | 8.44 |
| CHEMBL3263058 | — | — | 1 | 8.19 |
| CHEMBL3263072 | — | — | 1 | 8.01 |
| CHEMBL3263059 | — | — | 1 | 7.31 |
| CHEMBL3263061 | — | — | 1 | 7.27 |
| CHEMBL3263063 | — | — | 1 | - |
| CHEMBL3263064 | — | — | 1 | - |
| CHEMBL3263065 | — | — | 1 | - |
| CHEMBL3263060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263066 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3263056 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3263057 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3263076 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3263067 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3263069 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3263068 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3263071 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3263075 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3263074 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3263062 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3263070 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3263073 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3263058 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3263072 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3263059 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3263061 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3263063 | — | IC50 | - | — | - | |
| CHEMBL3263064 | — | IC50 | - | — | - | |
| CHEMBL3263065 | — | IC50 | - | — | - | |
| CHEMBL3263060 | — | IC50 | - | — | - |