Assay Detail
Binding
CHEMBL3267626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Enterococcus faecium VanX expressed in Escherichia coli BL21 (DE3) cells using D-alanyl-alpha-R-phenylthioglycine as substrate by colorimetric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterococcus faecium |
| Cell Type | BL21-DE3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
D-alanyl-D-alanine dipeptidase (CHEMBL1681622) ↗| Type | SINGLE PROTEIN |
| Organism | Enterococcus faecium |
Publication
Cell permeable vanX inhibitors as vancomycin re-sensitizing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.46 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260854 | — | — | 1 | 5.82 |
| CHEMBL3260858 | — | — | 1 | 5.56 |
| CHEMBL3260855 | — | — | 1 | 5.54 |
| CHEMBL3260856 | — | — | 1 | 5.21 |
| CHEMBL3260857 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260854 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3260858 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL3260855 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3260856 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL3260857 | — | Ki | = | 6840.0 | nM | 5.17 |