Assay Detail
Functional
CHEMBL3267832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HT-29 cell growth
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.06 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092179 | — | — | 1 | 8.10 |
| CHEMBL3092189 | — | — | 1 | 8.05 |
| CHEMBL3263996 | — | — | 1 | 7.60 |
| CHEMBL3263995 | — | — | 1 | 7.14 |
| CHEMBL3263994 | — | — | 1 | 6.22 |
| CHEMBL3263998 | — | — | 1 | 5.24 |
| CHEMBL3263997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092179 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3092189 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3263996 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3263995 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3263994 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3263998 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3263997 | — | IC50 | > | 10000.0 | nM | - |