Assay Detail
Binding
CHEMBL3268702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GGDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using FPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.49 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | — | 1 | 6.70 |
| CHEMBL3262352 | — | — | 1 | 6.42 |
| CHEMBL2315880 | — | — | 1 | 5.66 |
| CHEMBL3262351 | — | — | 1 | 4.77 |
| CHEMBL3262354 | — | — | 1 | 4.77 |
| CHEMBL3262353 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3262352 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2315880 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3262351 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3262354 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3262353 | — | IC50 | = | 23000.0 | nM | 4.64 |