Assay Detail
Binding
CHEMBL3269334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant soluble human BACE1 catalytic domain using QSY7-EISEVNLDAEFC-Europium-amide as substrate preincubated for 30 mins followed by substrate addition measured after 1.5 hrs by time-resolved FRET assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The evolution of amidine-based brain penetrant BACE1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.54 | 9.00 |
| Ki | 1 | 7.57 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261078 | — | — | 1 | 9.00 |
| CHEMBL3261079 | — | — | 1 | 8.08 |
| CHEMBL3261056 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261078 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3261079 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3261056 | — | Ki | = | 27.2 | nM | 7.57 |