Assay Detail
Binding
CHEMBL3269341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.39 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492634 | — | — | 1 | 7.77 |
| CHEMBL3261096 | — | — | 1 | 7.75 |
| CHEMBL3261090 | — | — | 1 | 7.66 |
| CHEMBL3261093 | — | — | 1 | 7.57 |
| CHEMBL3261088 | — | — | 1 | 7.57 |
| CHEMBL3261095 | — | — | 1 | 7.54 |
| CHEMBL3261094 | — | — | 1 | 7.44 |
| CHEMBL3261089 | — | — | 1 | 7.44 |
| CHEMBL3261084 | — | — | 1 | 7.43 |
| CHEMBL3261087 | — | — | 1 | 7.32 |
| CHEMBL226838 | — | — | 1 | 7.27 |
| CHEMBL3261083 | — | — | 1 | 7.24 |
| CHEMBL3261091 | — | — | 1 | 7.11 |
| CHEMBL3261092 | — | — | 1 | 7.07 |
| CHEMBL3261085 | — | — | 1 | 7.05 |
| CHEMBL3261086 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492634 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3261096 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3261090 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3261093 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3261088 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3261095 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3261094 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3261089 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3261084 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3261087 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL226838 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3261083 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3261091 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3261092 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3261085 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3261086 | — | IC50 | = | 106.0 | nM | 6.97 |