Assay Detail
Binding
CHEMBL3269346
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Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.94 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262896 | — | — | 2 | 9.65 |
| CHEMBL3262876 | — | — | 2 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262896 | — | IC50 | = | 0.2239 | nM | 9.65 |
| CHEMBL3262896 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3262876 | — | IC50 | = | 4.898 | nM | 8.31 |
| CHEMBL3262876 | — | IC50 | = | 5.3 | nM | 8.28 |