Assay Detail
Binding
CHEMBL3269457
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by heterologous competition binding assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Uracil nucleotide/cysteinyl leukotriene receptor (CHEMBL1075162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.45 | 5.79 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44793 | GAVESTINEL | 2.0 | 2 | 5.79 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 5.39 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44793 | GAVESTINEL | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL21333 | PRANLUKAST | Ki | = | 4060.0 | nM | 5.39 |
| CHEMBL787 | MONTELUKAST | Ki | = | 6540.0 | nM | 5.18 |
| CHEMBL44793 | GAVESTINEL | Activity | - | — | - |