Assay Detail
ADMET
CHEMBL3269568
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Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.45 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3264171 | — | — | 1 | 6.01 |
| CHEMBL3264175 | — | — | 1 | 5.97 |
| CHEMBL3264179 | — | — | 1 | 5.95 |
| CHEMBL3264180 | — | — | 1 | 5.91 |
| CHEMBL3264181 | — | — | 1 | 5.89 |
| CHEMBL3264185 | — | — | 1 | 5.84 |
| CHEMBL3264176 | — | — | 1 | 5.80 |
| CHEMBL3264183 | — | — | 1 | 5.80 |
| CHEMBL3264505 | — | — | 1 | 5.78 |
| CHEMBL3264182 | — | — | 1 | 5.74 |
| CHEMBL3264184 | — | — | 1 | 5.72 |
| CHEMBL3264178 | — | — | 1 | 5.71 |
| CHEMBL3264177 | — | — | 1 | 5.69 |
| CHEMBL3264507 | — | — | 1 | 5.67 |
| CHEMBL3264192 | — | — | 1 | 5.63 |
| CHEMBL3264172 | — | — | 1 | 5.59 |
| CHEMBL3264173 | — | — | 1 | 5.58 |
| CHEMBL3264174 | — | — | 1 | 5.56 |
| CHEMBL3264191 | — | — | 1 | 5.55 |
| CHEMBL3264508 | — | — | 1 | 5.42 |
| CHEMBL3264187 | — | — | 1 | 5.35 |
| CHEMBL3264509 | — | — | 1 | 5.33 |
| CHEMBL3264502 | — | — | 1 | 5.30 |
| CHEMBL3264504 | — | — | 1 | 5.28 |
| CHEMBL3264499 | — | — | 1 | 5.25 |
| CHEMBL3264186 | — | — | 1 | 5.23 |
| CHEMBL3264503 | — | — | 1 | 5.04 |
| CHEMBL3264500 | — | — | 1 | 4.98 |
| CHEMBL3264188 | — | — | 1 | 4.89 |
| CHEMBL3264498 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3264171 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3264175 | — | IC50 | = | 1068.0 | nM | 5.97 |
| CHEMBL3264179 | — | IC50 | = | 1111.0 | nM | 5.95 |
| CHEMBL3264180 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL3264181 | — | IC50 | = | 1281.0 | nM | 5.89 |
| CHEMBL3264185 | — | IC50 | = | 1448.0 | nM | 5.84 |
| CHEMBL3264176 | — | IC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL3264183 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL3264505 | — | IC50 | = | 1648.0 | nM | 5.78 |
| CHEMBL3264182 | — | IC50 | = | 1809.0 | nM | 5.74 |
| CHEMBL3264184 | — | IC50 | = | 1922.0 | nM | 5.72 |
| CHEMBL3264178 | — | IC50 | = | 1929.0 | nM | 5.71 |
| CHEMBL3264177 | — | IC50 | = | 2044.0 | nM | 5.69 |
| CHEMBL3264507 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3264192 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3264172 | — | IC50 | = | 2565.0 | nM | 5.59 |
| CHEMBL3264173 | — | IC50 | = | 2643.0 | nM | 5.58 |
| CHEMBL3264174 | — | IC50 | = | 2729.0 | nM | 5.56 |
| CHEMBL3264191 | — | IC50 | = | 2828.0 | nM | 5.55 |
| CHEMBL3264508 | — | IC50 | = | 3771.0 | nM | 5.42 |
| CHEMBL3264187 | — | IC50 | = | 4463.0 | nM | 5.35 |
| CHEMBL3264509 | — | IC50 | = | 4678.0 | nM | 5.33 |
| CHEMBL3264502 | — | IC50 | = | 4972.0 | nM | 5.30 |
| CHEMBL3264504 | — | IC50 | = | 5278.0 | nM | 5.28 |
| CHEMBL3264499 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL3264186 | — | IC50 | = | 5854.0 | nM | 5.23 |
| CHEMBL3264503 | — | IC50 | = | 9212.0 | nM | 5.04 |
| CHEMBL3264500 | — | IC50 | = | 10419.0 | nM | 4.98 |
| CHEMBL3264188 | — | IC50 | = | 12797.0 | nM | 4.89 |
| CHEMBL3264498 | — | IC50 | = | 13823.0 | nM | 4.86 |
| CHEMBL3264497 | — | IC50 | = | 14096.0 | nM | 4.85 |
| CHEMBL3264501 | — | IC50 | = | 14381.0 | nM | 4.84 |
| CHEMBL3264190 | — | IC50 | = | 14480.0 | nM | 4.84 |
| CHEMBL3264506 | — | IC50 | = | 35417.0 | nM | 4.45 |