Assay Detail
Functional
CHEMBL3269591
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Cytotoxicity against human KB cells assessed as inhibition of cell growth after 3 days by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.47 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | — | 1 | 8.90 |
| CHEMBL3264568 | — | — | 1 | 8.46 |
| CHEMBL3264572 | — | — | 1 | 8.43 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.41 |
| CHEMBL3264560 | — | — | 1 | 8.09 |
| CHEMBL3264916 | — | — | 1 | 7.80 |
| CHEMBL3264567 | — | — | 1 | 7.64 |
| CHEMBL3264569 | — | — | 1 | 7.62 |
| CHEMBL3264551 | — | — | 1 | 7.51 |
| CHEMBL3264573 | — | — | 1 | 7.31 |
| CHEMBL3264559 | — | — | 1 | 7.20 |
| CHEMBL3264574 | — | — | 1 | 7.16 |
| CHEMBL3264555 | — | — | 1 | 7.11 |
| CHEMBL3264553 | — | — | 1 | 7.06 |
| CHEMBL3264554 | — | — | 1 | 6.97 |
| CHEMBL3264561 | — | — | 1 | 6.81 |
| CHEMBL3264552 | — | — | 1 | 6.79 |
| CHEMBL3264575 | — | — | 1 | 6.73 |
| CHEMBL3264570 | — | — | 1 | 6.70 |
| CHEMBL3264914 | — | — | 1 | 6.63 |
| CHEMBL3264556 | — | — | 1 | - |
| CHEMBL3264557 | — | — | 1 | - |
| CHEMBL3264558 | — | — | 1 | - |
| CHEMBL3264562 | — | — | 1 | - |
| CHEMBL3264563 | — | — | 1 | - |
| CHEMBL3264564 | — | — | 1 | - |
| CHEMBL3264565 | — | — | 1 | - |
| CHEMBL3264566 | — | — | 1 | - |
| CHEMBL3264571 | — | — | 1 | - |
| CHEMBL3264913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL3264568 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3264572 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3264560 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3264916 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL3264567 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3264569 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL3264551 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL3264573 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3264559 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3264574 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL3264555 | — | IC50 | = | 77.4 | nM | 7.11 |
| CHEMBL3264553 | — | IC50 | = | 86.2 | nM | 7.06 |
| CHEMBL3264554 | — | IC50 | = | 107.4 | nM | 6.97 |
| CHEMBL3264561 | — | IC50 | = | 155.4 | nM | 6.81 |
| CHEMBL3264552 | — | IC50 | = | 160.5 | nM | 6.79 |
| CHEMBL3264575 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL3264570 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3264914 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL3264556 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264557 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264558 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264562 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264563 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264564 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264565 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264566 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264571 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264913 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264915 | — | IC50 | > | 269.0 | nM | - |
| CHEMBL3264917 | — | IC50 | > | 269.0 | nM | - |