Assay Detail
Binding
CHEMBL3269595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPAR-alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of the first potent, selective and bioavailable PPARα antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.00 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424133 | LY-518674 | 2.0 | 1 | 7.38 |
| CHEMBL410478 | — | — | 1 | 6.62 |
| CHEMBL3264932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424133 | LY-518674 | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL410478 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3264932 | — | EC50 | > | 100000.0 | nM | - |