Assay Detail
Binding
CHEMBL3269910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human Jurkat cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Nuclear factor NF-kappa-B complex (CHEMBL2094258) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.72 | 4.72 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3264621 | — | — | 2 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3264621 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3264621 | — | Inhibition | - | % | - |