Assay Detail
Functional
CHEMBL3270103
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Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as stimulation of [3H]inositol phosphate accumulation by liquid scintillation counting
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.96 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261372 | — | — | 1 | 7.70 |
| CHEMBL3261369 | — | — | 1 | 7.64 |
| CHEMBL3261376 | — | — | 1 | 7.40 |
| CHEMBL3261375 | — | — | 1 | 7.33 |
| CHEMBL3261360 | — | — | 1 | 7.27 |
| CHEMBL3261378 | — | — | 1 | 7.16 |
| CHEMBL3261368 | — | — | 1 | 7.08 |
| CHEMBL3261366 | — | — | 1 | 7.04 |
| CHEMBL3261367 | — | — | 1 | 7.02 |
| CHEMBL3261362 | — | — | 1 | 7.00 |
| CHEMBL3261363 | — | — | 1 | 6.98 |
| CHEMBL3261365 | — | — | 1 | 6.94 |
| CHEMBL3261374 | — | — | 1 | 6.89 |
| CHEMBL3261364 | — | — | 1 | 6.85 |
| CHEMBL3261377 | — | — | 1 | 6.70 |
| CHEMBL3261371 | — | — | 1 | 6.60 |
| CHEMBL3261370 | — | — | 1 | 6.52 |
| CHEMBL3261373 | — | — | 1 | 6.39 |
| CHEMBL3261361 | — | — | 1 | 6.37 |
| CHEMBL3261359 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261372 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3261369 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3261376 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3261375 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3261360 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3261378 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3261368 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3261366 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3261367 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3261362 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3261363 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL3261365 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3261374 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3261364 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3261377 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3261371 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3261370 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3261373 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3261361 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3261359 | — | EC50 | = | 470.0 | nM | 6.33 |