Assay Detail
Binding
CHEMBL3270317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Flt3 in human MV411 cells assessed as assessed as proliferation after 72 hrs incubation by spectrophotometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.25 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475251 | R-406 | 2.0 | 1 | 8.00 |
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475251 | R-406 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3265032 | ENTOSPLETINIB | EC50 | = | 327.0 | nM | 6.49 |