Assay Detail
Binding
CHEMBL3270419
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Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.54 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7146 | — | — | 1 | 7.60 |
| CHEMBL268439 | — | — | 1 | 7.35 |
| CHEMBL266026 | — | — | 1 | 7.30 |
| CHEMBL269122 | — | — | 1 | 7.28 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.14 |
| CHEMBL2324864 | — | — | 1 | 7.10 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.05 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.99 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.83 |
| CHEMBL6724 | — | — | 1 | 6.74 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.61 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.56 |
| CHEMBL224292 | — | — | 1 | 6.55 |
| CHEMBL6633 | — | — | 1 | 6.49 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.47 |
| CHEMBL7087 | — | — | 1 | 6.43 |
| CHEMBL265674 | — | — | 1 | 6.42 |
| CHEMBL6753 | — | — | 1 | 6.41 |
| CHEMBL7092 | — | — | 1 | 6.40 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.38 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.36 |
| CHEMBL6852 | — | — | 1 | 6.34 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.33 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.33 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.32 |
| CHEMBL266240 | — | — | 1 | 6.30 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.29 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.28 |
| CHEMBL6853 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7146 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL268439 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL266026 | — | Ki | = | 50.1 | nM | 7.30 |
| CHEMBL269122 | — | Ki | = | 52.3 | nM | 7.28 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 64.1 | nM | 7.19 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 72.1 | nM | 7.14 |
| CHEMBL2324864 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL6724 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL26 | SULPIRIDE | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL224292 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL6633 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL7087 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL265674 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL6753 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL7092 | — | Ki | = | 396.0 | nM | 6.40 |
| CHEMBL118 | CELECOXIB | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL310671 | SACCHARIN | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL6852 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL328560 | SULTHIAME | Ki | = | 463.0 | nM | 6.33 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 467.0 | nM | 6.33 |
| CHEMBL414 | CARZENIDE | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL266240 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL419 | MAFENIDE | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL77517 | INDISULAM | Ki | = | 525.0 | nM | 6.28 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 593.0 | nM | 6.23 |
| CHEMBL6853 | — | Ki | = | 592.0 | nM | 6.23 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 624.0 | nM | 6.21 |
| CHEMBL2324869 | — | Ki | = | 622.0 | nM | 6.21 |
| CHEMBL6919 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL6784 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 745.0 | nM | 6.13 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL865 | VALDECOXIB | Ki | = | 879.0 | nM | 6.06 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 882.0 | nM | 6.05 |
| CHEMBL2324868 | — | Ki | = | 933.0 | nM | 6.03 |