Assay Detail
Binding
CHEMBL3270420
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Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.58 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.50 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.48 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.46 |
| CHEMBL6633 | — | — | 1 | 7.42 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.40 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.27 |
| CHEMBL268439 | — | — | 1 | 7.19 |
| CHEMBL7146 | — | — | 1 | 7.15 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.14 |
| CHEMBL266026 | — | — | 1 | 7.06 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.98 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.89 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.84 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.75 |
| CHEMBL6784 | — | — | 1 | 6.66 |
| CHEMBL6919 | — | — | 1 | 6.63 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.59 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.35 |
| CHEMBL266240 | — | — | 1 | 6.19 |
| CHEMBL6753 | — | — | 1 | 6.12 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.01 |
| CHEMBL6724 | — | — | 1 | 5.91 |
| CHEMBL6853 | — | — | 1 | 5.87 |
| CHEMBL7092 | — | — | 1 | 5.83 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.73 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 5.63 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 5.61 |
| CHEMBL265674 | — | — | 1 | 5.59 |
| CHEMBL7087 | — | — | 1 | 5.46 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL26 | SULPIRIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL6633 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL268439 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL7146 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL266026 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL77517 | INDISULAM | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL6784 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL6919 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL414 | CARZENIDE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL266240 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL6753 | — | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 973.0 | nM | 6.01 |
| CHEMBL6724 | — | Ki | = | 1235.0 | nM | 5.91 |
| CHEMBL6853 | — | Ki | = | 1359.0 | nM | 5.87 |
| CHEMBL7092 | — | Ki | = | 1463.0 | nM | 5.83 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 1845.0 | nM | 5.73 |
| CHEMBL419 | MAFENIDE | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL265674 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL7087 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL2324868 | — | Ki | - | — | - | |
| CHEMBL2324869 | — | Ki | - | — | - | |
| CHEMBL224292 | — | Ki | - | — | - | |
| CHEMBL2324864 | — | Ki | - | — | - | |
| CHEMBL269122 | — | Ki | - | — | - | |
| CHEMBL328560 | SULTHIAME | Ki | - | — | - | |
| CHEMBL118 | CELECOXIB | Ki | - | — | - | |
| CHEMBL865 | VALDECOXIB | Ki | - | — | - | |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | - | — | - | |
| CHEMBL6852 | — | Ki | - | — | - | |
| CHEMBL310671 | SACCHARIN | Ki | - | — | - |