Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3270423

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-B expressed in baculovirus infected insect cell microsomes assessed as p-tyramine conversion to resorufin and H2O2 after 15 mins by fluorimetric assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO.
Pan ZX, He X, Chen YY, Tang WJ, Shi JB, Tang YL, Song BA, Li J, Liu XH.
Eur J Med Chem (2014) 80 : 278 -284
PubMed 24793878 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.90 6.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445184 1 6.03
CHEMBL3261198 1 5.53
CHEMBL509345 1 5.48
CHEMBL3261201 1 5.33
CHEMBL3261204 1 5.15
CHEMBL92401 IPRONIAZID 2.0 1 5.11
CHEMBL3261211 1 5.09
CHEMBL3261200 1 4.98
CHEMBL1388493 1 4.87
CHEMBL3261212 1 4.83
CHEMBL3261213 1 4.72
CHEMBL3261202 1 4.70
CHEMBL3261203 1 4.67
CHEMBL3261210 1 4.64
CHEMBL3261207 1 4.53
CHEMBL3261199 1 4.45
CHEMBL3261209 1 4.41
CHEMBL3261206 1 4.34
CHEMBL3261208 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445184 IC50 = 930.0 nM 6.03
CHEMBL3261198 IC50 = 2960.0 nM 5.53
CHEMBL509345 IC50 = 3300.0 nM 5.48
CHEMBL3261201 IC50 = 4680.0 nM 5.33
CHEMBL3261204 IC50 = 7090.0 nM 5.15
CHEMBL92401 IPRONIAZID IC50 = 7800.0 nM 5.11
CHEMBL3261211 IC50 = 8050.0 nM 5.09
CHEMBL3261200 IC50 = 10560.0 nM 4.98
CHEMBL1388493 IC50 = 13460.0 nM 4.87
CHEMBL3261212 IC50 = 14710.0 nM 4.83
CHEMBL3261213 IC50 = 19060.0 nM 4.72
CHEMBL3261202 IC50 = 20170.0 nM 4.70
CHEMBL3261203 IC50 = 21550.0 nM 4.67
CHEMBL3261210 IC50 = 22800.0 nM 4.64
CHEMBL3261207 IC50 = 29420.0 nM 4.53
CHEMBL3261199 IC50 = 35400.0 nM 4.45
CHEMBL3261209 IC50 = 39110.0 nM 4.41
CHEMBL3261206 IC50 = 46070.0 nM 4.34
CHEMBL3261208 IC50 = 50030.0 nM 4.30