Assay Detail
Functional
CHEMBL3270514
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Antiviral activity against Human cytomegalovirus Towne infected in HFF assessed as inhibition of viral replication by measuring pp28 expression at 72 hrs post-infection by luciferase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Digitoxin analogues with improved anticytomegalovirus activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.24 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651649 | RAMNODIGIN | 2.0 | 1 | 8.42 |
| CHEMBL1651648 | — | — | 1 | 8.32 |
| CHEMBL3265172 | — | — | 1 | 8.14 |
| CHEMBL1819284 | — | — | 1 | 7.83 |
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 7.63 |
| CHEMBL1819286 | — | — | 1 | 7.58 |
| CHEMBL1819282 | — | — | 1 | 7.43 |
| CHEMBL1651625 | — | — | 1 | 7.43 |
| CHEMBL1819285 | — | — | 1 | 6.95 |
| CHEMBL1819287 | — | — | 1 | 6.68 |
| CHEMBL1819283 | — | — | 1 | 6.63 |
| CHEMBL1819288 | — | — | 1 | 6.50 |
| CHEMBL1819399 | — | — | 1 | 6.10 |
| CHEMBL1819281 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651649 | RAMNODIGIN | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1651648 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3265172 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1819284 | — | EC50 | = | 14.8 | nM | 7.83 |
| CHEMBL254219 | DIGITOXIN | EC50 | = | 23.3 | nM | 7.63 |
| CHEMBL1819286 | — | EC50 | = | 26.6 | nM | 7.58 |
| CHEMBL1819282 | — | EC50 | = | 36.7 | nM | 7.43 |
| CHEMBL1651625 | — | EC50 | = | 37.5 | nM | 7.43 |
| CHEMBL1819285 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1819287 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL1819283 | — | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL1819288 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1819399 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1819281 | — | EC50 | = | 2080.0 | nM | 5.68 |