Assay Detail

CHEMBL3270641

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Functional

Cytotoxicity against human A549 cells after 48 hrs by SRB assay

ChEMBL ↗

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Target

A549 (CHEMBL392) ↗

Open DB target context

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A549 (CHEMBL392) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A549

CHEMBL392

Anchored from Assay target.

Protein identity A549

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A549
Confidence	1 — Organism
Curated By	Autocuration

Target

A549 (CHEMBL392) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.

Hsiao CJ, Hsiao G, Chen WL, Wang SW, Chiang CP, Liu LY, Guh JH, Lee TH, Chung CL.
J Nat Prod (2014) 77 : 758 -765
PubMed 24588135 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.57	5.57
Activity	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL463175	CEPHALOCHROMIN	—	2	5.57

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL463175	CEPHALOCHROMIN	IC50	=	2720.0	nM	5.57
CHEMBL463175	CEPHALOCHROMIN	Activity		-	—	-