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Assay Detail

CHEMBL3270911

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]N/OFQ from human nociceptin opioid receptor transfected in CHO cell membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Nociceptin receptor (CHEMBL2014)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Journigan VB, Polgar WE, Khroyan TV, Zaveri NT.
Bioorg Med Chem (2014) 22 : 2508 -2516
PubMed 24657054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.19 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL396460 NOCICEPTIN 1 9.92
CHEMBL3262542 1 8.68
CHEMBL3262545 1 8.52
CHEMBL3262544 1 8.50
CHEMBL3262543 1 8.47
CHEMBL3262546 1 8.06
CHEMBL3262548 1 7.96
CHEMBL3262547 1 7.92
CHEMBL3262549 1 7.12
CHEMBL3262551 1 6.72
CHEMBL3262550 1 -
CHEMBL3262552 1 -
CHEMBL3262553 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL396460 NOCICEPTIN Ki = 0.12 nM 9.92
CHEMBL3262542 Ki = 2.1 nM 8.68
CHEMBL3262545 Ki = 2.99 nM 8.52
CHEMBL3262544 Ki = 3.16 nM 8.50
CHEMBL3262543 Ki = 3.41 nM 8.47
CHEMBL3262546 Ki = 8.63 nM 8.06
CHEMBL3262548 Ki = 11.1 nM 7.96
CHEMBL3262547 Ki = 12.0 nM 7.92
CHEMBL3262549 Ki = 76.6 nM 7.12
CHEMBL3262551 Ki = 188.7 nM 6.72
CHEMBL3262550 Ki > 10000.0 nM -
CHEMBL3262552 Ki > 10000.0 nM -
CHEMBL3262553 Ki > 10000.0 nM -