Assay Detail
Binding
CHEMBL3270913
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Displacement of [3H]U69,593 from human kappa opioid receptor transfected in CHO cell membranes after 60 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.88 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440765 | U-69593 | — | 1 | 8.98 |
| CHEMBL3262548 | — | — | 1 | 7.89 |
| CHEMBL3262547 | — | — | 1 | 7.82 |
| CHEMBL3262546 | — | — | 1 | 7.25 |
| CHEMBL3262549 | — | — | 1 | 7.05 |
| CHEMBL3262544 | — | — | 1 | 6.82 |
| CHEMBL3262545 | — | — | 1 | 6.74 |
| CHEMBL3262551 | — | — | 1 | 6.33 |
| CHEMBL3262542 | — | — | 1 | 6.29 |
| CHEMBL3262543 | — | — | 1 | 6.09 |
| CHEMBL3262552 | — | — | 1 | 5.86 |
| CHEMBL3262550 | — | — | 1 | 5.38 |
| CHEMBL3262553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440765 | U-69593 | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL3262548 | — | Ki | = | 12.82 | nM | 7.89 |
| CHEMBL3262547 | — | Ki | = | 15.13 | nM | 7.82 |
| CHEMBL3262546 | — | Ki | = | 56.3 | nM | 7.25 |
| CHEMBL3262549 | — | Ki | = | 88.4 | nM | 7.05 |
| CHEMBL3262544 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL3262545 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL3262551 | — | Ki | = | 467.7 | nM | 6.33 |
| CHEMBL3262542 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL3262543 | — | Ki | = | 814.0 | nM | 6.09 |
| CHEMBL3262552 | — | Ki | = | 1367.0 | nM | 5.86 |
| CHEMBL3262550 | — | Ki | = | 4171.0 | nM | 5.38 |
| CHEMBL3262553 | — | Ki | > | 10000.0 | nM | - |