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Assay Detail

CHEMBL3271231

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytostatic activity against mouse L1210 cells assessed as inhibition of cell proliferation after 48 hrs by Coulter counter analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides.
Velanguparackel W, Hamon N, Balzarini J, McGuigan C, Westwell AD.
Bioorg Med Chem Lett (2014) 24 : 2240 -2243
PubMed 24751439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.29 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105318 ALOVUDINE 2.0 1 7.09
CHEMBL3260473 1 5.92
CHEMBL3260470 1 5.72
CHEMBL3260469 1 5.54
CHEMBL3260465 1 5.52
CHEMBL3260474 1 5.42
CHEMBL3260118 1 5.36
CHEMBL3260471 1 5.28
CHEMBL3260464 1 5.24
CHEMBL3260466 1 5.22
CHEMBL3260120 1 5.20
CHEMBL3260117 1 5.09
CHEMBL3260119 1 4.64
CHEMBL3260467 1 4.62
CHEMBL3260468 1 4.44
CHEMBL3260472 1 4.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105318 ALOVUDINE IC50 = 81.0 nM 7.09
CHEMBL3260473 IC50 = 1200.0 nM 5.92
CHEMBL3260470 IC50 = 1900.0 nM 5.72
CHEMBL3260469 IC50 = 2900.0 nM 5.54
CHEMBL3260465 IC50 = 3000.0 nM 5.52
CHEMBL3260474 IC50 = 3800.0 nM 5.42
CHEMBL3260118 IC50 = 4400.0 nM 5.36
CHEMBL3260471 IC50 = 5200.0 nM 5.28
CHEMBL3260464 IC50 = 5800.0 nM 5.24
CHEMBL3260466 IC50 = 6000.0 nM 5.22
CHEMBL3260120 IC50 = 6300.0 nM 5.20
CHEMBL3260117 IC50 = 8200.0 nM 5.09
CHEMBL3260119 IC50 = 23000.0 nM 4.64
CHEMBL3260467 IC50 = 24000.0 nM 4.62
CHEMBL3260468 IC50 = 36000.0 nM 4.44
CHEMBL3260472 IC50 = 43000.0 nM 4.37