Assay Detail
Binding
CHEMBL3271544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-bromo-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide from sigma-2 receptor in mouse EMT6 cell membranes after 60 mins by Scatchard plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.38 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387741 | — | — | 1 | 8.97 |
| CHEMBL226539 | — | — | 1 | 8.18 |
| CHEMBL60048 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387741 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL226539 | — | Ki | = | 6.59 | nM | 8.18 |
| CHEMBL60048 | — | Ki | = | 10.3 | nM | 7.99 |