Assay Detail
Functional
CHEMBL3271844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against intracellular amastigote form of Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase gene infected in mouse J774A1 cells after 72 hrs by luminescence analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.09 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336134 | — | — | 1 | 5.77 |
| CHEMBL2331603 | — | — | 1 | 5.27 |
| CHEMBL3262539 | — | — | 1 | 5.24 |
| CHEMBL3262271 | — | — | 1 | 5.24 |
| CHEMBL2335724 | — | — | 1 | 5.20 |
| CHEMBL3262541 | — | — | 1 | 5.19 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.08 |
| CHEMBL2336169 | — | — | 1 | 4.97 |
| CHEMBL3262540 | — | — | 1 | 4.96 |
| CHEMBL560422 | LESPEOL | — | 1 | 4.78 |
| CHEMBL2079699 | — | — | 1 | 4.30 |
| CHEMBL3262272 | — | — | 1 | - |
| CHEMBL2336157 | — | — | 1 | - |
| CHEMBL2336173 | — | — | 1 | - |
| CHEMBL2336172 | — | — | 1 | - |
| CHEMBL3262270 | — | — | 1 | - |
| CHEMBL3262537 | — | — | 1 | - |
| CHEMBL3262538 | — | — | 1 | - |
| CHEMBL2336170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336134 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2331603 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3262539 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3262271 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2335724 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3262541 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2336169 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3262540 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL560422 | LESPEOL | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL2079699 | — | IC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL3262272 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2336157 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2336173 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2336172 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3262270 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3262537 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3262538 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2336170 | — | IC50 | > | 20000.0 | nM | - |