Assay Detail
Binding
CHEMBL3279769
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Competitive inhibition of Escherichia coli thymidylate synthetase using 5-[3H]-dUMP as substrate after 7 mins by scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.99 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236552 | — | — | 1 | 7.00 |
| CHEMBL1160818 | — | — | 1 | 5.40 |
| CHEMBL3273353 | — | — | 1 | 4.75 |
| CHEMBL3272995 | — | — | 1 | 4.60 |
| CHEMBL3273352 | — | — | 1 | 4.60 |
| CHEMBL3272994 | — | — | 1 | 4.38 |
| CHEMBL3272996 | — | — | 1 | 4.19 |
| CHEMBL3273351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236552 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1160818 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3273353 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3272995 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL3273352 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL3272994 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL3272996 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL3273351 | — | Ki | = | 135000.0 | nM | - |