Assay Detail
Binding
CHEMBL3279770
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Competitive inhibition of calf thymus thymidylate synthetase using 5-[3H]-dUMP as substrate after 10 mins by scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.60 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160818 | — | — | 1 | 5.40 |
| CHEMBL3273353 | — | — | 1 | 4.68 |
| CHEMBL3272994 | — | — | 1 | 4.50 |
| CHEMBL3273352 | — | — | 1 | 4.48 |
| CHEMBL3272995 | — | — | 1 | 4.38 |
| CHEMBL3272996 | — | — | 1 | 4.14 |
| CHEMBL3273351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160818 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3273353 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL3272994 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL3273352 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL3272995 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL3272996 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL3273351 | — | Ki | = | 130000.0 | nM | - |