Assay Detail
Binding
CHEMBL3280463
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Reversible mixed-type inhibition of electric eel acetylcholinesterase using acetylcholine bromide as substrate assessed as free enzyme-inhibitor complex by Lineweaver-Burk plot analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.95 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3276408 | — | — | 1 | 8.68 |
| CHEMBL3276410 | — | — | 1 | 8.18 |
| CHEMBL3276411 | — | — | 1 | 8.00 |
| CHEMBL3276412 | — | — | 1 | 6.75 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | -1.0 | 1 | 6.68 |
| CHEMBL3276417 | — | — | 1 | 6.60 |
| CHEMBL3276418 | — | — | 1 | 6.55 |
| CHEMBL3276429 | — | — | 1 | 6.30 |
| CHEMBL3276416 | — | — | 1 | 6.28 |
| CHEMBL1200933 | HEXAFLUORENIUM BROMIDE | 4.0 | 1 | 5.89 |
| CHEMBL3276424 | — | — | 1 | 5.75 |
| CHEMBL3276430 | — | — | 1 | 5.54 |
| CHEMBL3276414 | — | — | 1 | 5.50 |
| CHEMBL3276413 | — | — | 1 | 5.25 |
| CHEMBL3276422 | — | — | 1 | 5.05 |
| CHEMBL3276423 | — | — | 1 | 5.03 |
| CHEMBL3276420 | — | — | 1 | 4.92 |
| CHEMBL3276427 | — | — | 1 | 4.75 |
| CHEMBL3276415 | — | — | 1 | 4.66 |
| CHEMBL3276419 | — | — | 1 | 4.51 |
| CHEMBL3276425 | — | — | 1 | 4.08 |
| CHEMBL3276428 | — | — | 1 | - |
| CHEMBL3276432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3276408 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3276410 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL3276411 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3276412 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3276417 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3276418 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL3276429 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3276416 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL1200933 | HEXAFLUORENIUM BROMIDE | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3276424 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3276430 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3276414 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3276413 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL3276422 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL3276423 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL3276420 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3276427 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3276415 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL3276419 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL3276425 | — | Ki | = | 83000.0 | nM | 4.08 |
| CHEMBL3276428 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL3276432 | — | Ki | = | 320000.0 | nM | - |