Assay Detail
Binding
CHEMBL3280465
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Reversible mixed-type inhibition of horse serum butyrylcholinesterase using acetylcholine bromide as substrate assessed as free enzyme-inhibitor complex by Lineweaver-Burk plot analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.11 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3276408 | — | — | 1 | 8.14 |
| CHEMBL3276410 | — | — | 1 | 7.57 |
| CHEMBL3276418 | — | — | 1 | 7.27 |
| CHEMBL3276412 | — | — | 1 | 7.24 |
| CHEMBL3276417 | — | — | 1 | 7.21 |
| CHEMBL3276416 | — | — | 1 | 6.92 |
| CHEMBL3276429 | — | — | 1 | 6.62 |
| CHEMBL1200933 | HEXAFLUORENIUM BROMIDE | 4.0 | 1 | 6.47 |
| CHEMBL3276411 | — | — | 1 | 6.44 |
| CHEMBL3276423 | — | — | 1 | 6.07 |
| CHEMBL3276424 | — | — | 1 | 6.04 |
| CHEMBL3276413 | — | — | 1 | 5.96 |
| CHEMBL3276414 | — | — | 1 | 5.89 |
| CHEMBL3276430 | — | — | 1 | 5.89 |
| CHEMBL3276415 | — | — | 1 | 5.82 |
| CHEMBL3276422 | — | — | 1 | 5.27 |
| CHEMBL3276427 | — | — | 1 | 4.50 |
| CHEMBL3276419 | — | — | 1 | 4.43 |
| CHEMBL3276420 | — | — | 1 | 4.39 |
| CHEMBL3276425 | — | — | 1 | 4.10 |
| CHEMBL3276428 | — | — | 1 | - |
| CHEMBL3276432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3276408 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL3276410 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3276418 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3276412 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3276417 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL3276416 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3276429 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1200933 | HEXAFLUORENIUM BROMIDE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3276411 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL3276423 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL3276424 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL3276413 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3276414 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3276430 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3276415 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3276422 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL3276427 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL3276419 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL3276420 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL3276425 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL3276428 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL3276432 | — | Ki | = | 120000.0 | nM | - |