Assay Detail
Binding
CHEMBL3280468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversible competitive inhibition of electric eel acetylcholinesterase using acetylcholine bromide as substrate assessed as free enzyme-inhibitor complex by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.95 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3276432 | — | — | 1 | 7.68 |
| CHEMBL3276431 | — | — | 1 | 7.68 |
| CHEMBL3276421 | — | — | 1 | 6.42 |
| CHEMBL3276426 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3276432 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3276431 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3276421 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL3276426 | — | Ki | = | 950.0 | nM | 6.02 |