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Assay Detail

CHEMBL3280958

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of respiration in mouse Ehrlich ascites cells after 30 mins incubation at 37 degC by whole cell model
30
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Ehrlich
Confidence 1 — Organism
Curated By Autocuration

Target

Ehrlich (CHEMBL614641)
Type CELL-LINE
Organism Mus musculus

Publication

Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration.
Shah KJ, Coats EA.
J Med Chem (1977) 20 : 1001 -1006
PubMed 894670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 4.62 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL157654 2 4.82
CHEMBL157710 2 4.42
CHEMBL158890 2 -
CHEMBL344461 2 -
CHEMBL345688 2 -
CHEMBL347711 2 -
CHEMBL141025 2 -
CHEMBL138298 2 -
CHEMBL139244 2 -
CHEMBL160456 2 -
CHEMBL139078 2 -
CHEMBL343799 2 -
CHEMBL138027 2 -
CHEMBL139402 2 -
CHEMBL1161215 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL157654 IC50 = 15135.61 nM 4.82
CHEMBL157654 IC50 = 15000.0 nM 4.82
CHEMBL157710 IC50 = 38000.0 nM 4.42
CHEMBL157710 IC50 = 38904.51 nM 4.41
CHEMBL158890 IC50 = 1060000.0 nM -
CHEMBL344461 IC50 = 140000.0 nM -
CHEMBL1161215 IC50 = 1300000.0 nM -
CHEMBL139402 IC50 = 3400000.0 nM -
CHEMBL138027 IC50 = 910000.0 nM -
CHEMBL343799 IC50 = 1790000.0 nM -
CHEMBL139078 IC50 = 5770000.0 nM -
CHEMBL160456 IC50 = 5820000.0 nM -
CHEMBL139244 IC50 = 580000.0 nM -
CHEMBL138298 IC50 = 470000.0 nM -
CHEMBL141025 IC50 = 790000.0 nM -
CHEMBL347711 IC50 = 520000.0 nM -
CHEMBL345688 IC50 = 500000.0 nM -
CHEMBL344461 IC50 = 144543.98 nM -
CHEMBL345688 IC50 = 501187.23 nM -
CHEMBL347711 IC50 = 524807.46 nM -
CHEMBL141025 IC50 = 794328.23 nM -
CHEMBL138298 IC50 = 467735.14 nM -
CHEMBL139244 IC50 = 575439.94 nM -
CHEMBL160456 IC50 = 5754399.37 nM -
CHEMBL139078 IC50 = 5754399.37 nM -
CHEMBL343799 IC50 = 1778279.41 nM -
CHEMBL138027 IC50 = 912010.84 nM -
CHEMBL139402 IC50 = 3388441.56 nM -
CHEMBL1161215 IC50 = 1318256.74 nM -
CHEMBL158890 IC50 = 1047128.55 nM -